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Tirzepatide advantages in trials: Greater total weight loss, stronger HbA1c reduction, favorable body composition changes, long-term durability data Semaglutide advantages in trials: Established cardiovascular outcomes data (SELECT trial), longer real-world track record, oral formulation option Both medications: Require lifestyle changes to maximize results

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Likewise, GLP-RAs inhibit platelet aggregation and prevent thrombosis [109]