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Hutchins et al

doi: 10.3389/fnut.2021.726770, 107

Phase I Detoxification Genes: CYP450 Family Many toxicants whether ingested, inhaled, or created in our bodies are broken down by the Cytochrome P450 (CYP450) family of enzymes in phase I detoxification

El riesgo de carcinoma medular de tiroides, observado en roedores, no se ha confirmado en humanos, pero estos frmacos estn contraindicados en pacientes con historia personal o familiar de este tumor

Methylfolate provides the biologically active form without requiring DHFR conversion and may therefore be preferable where reduced enzyme activity is suspected