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DOI: 10.1080/15563650.2019.1606432 Aroda VR et al, "Long-term metformin use and vitamin B12 deficiency in the Diabetes Prevention Program Outcomes Study." Journal of Clinical Endocrinology and Metabolism, Feb

Step 6: Follow your doctors instructions regarding your prescribed dose and report any serious side effects to your healthcare provider

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Gastrointestinal side effects may lead to treatment discontinuation in some patients, though severe cases remain rare and can be mitigated with appropriate monitoring (62)