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Diabetes 51(6):19381948 Frustaci A, Chimenti C, Setoguchi M, Guerra S, Corsello S, Crea F, Leri A, Kajstura J, Anversa P, Maseri A (1999) Cell death in acromegalic cardiomyopathy

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Neurology 102 , 3350 (2024)

The hydrazone linkage is relatively stable and hydrolyzes very slowly at pH 7.4 while at low pH 5-6 in endosomal/lysosomal compartments the rate of hydrolysis is increased