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Higher doses can stall the very same process, or tip into outright toxicity over longer exposures, where free copper drifting loose from the complex starts driving oxidative damage

Minoxidil vs Finasteride: Whats the Difference

2010;299(6):C148592

This results in four alleles of GSTP1 : wild-type GSTP1 *A (Ile105 + Ala114), GSTP1 *B (Val105 + Ala114), GSTP1 *C (Val105 + Val114), and GSTP1 *D (Ile105 + Val114)