Birth of the incretin concept The same year Lim and Kosaka published their hypothesis, the Belgian physiologist La Barre attempted to purify secretin with Eugene Still, a colleague at the University of Chicago
At the same time, GLP-1s are now understood to have potent anti-inflammatory effects in the brain that could reduce depression for individuals with depression related to inflammation
In the UK, semaglutide (Ozempic for diabetes, Wegovy for weight management), dulaglutide (Trulicity for diabetes), and liraglutide (Victoza for diabetes, Saxenda for weight management) are commonly prescribed options
My Honest Take Look, Ive been doing this for a while, and GLP-1 medications are some of the most impressive treatments Ive seen for diabetes and weight management
Mechanism of Action Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs) are a class of medications that mimic the natural hormone GLP-1, produced by the small intestine (23)
Some patients benefit from staying at a lower stable dose longer rather than rapid titration, trading slightly slower weight loss for better exercise performance
