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1 Vitamin B 12 has been demonstrated to be safe in doses up to 1,000 times the recommended dietary allowance and is safe in pregnancy

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References Uribe PM, Kawas LH, Harding JW, Coffin AB

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So, the problem doesnt appear to be directly driven by hyperglycemia but possibly by other factors related to oxidative stress and inflammation two major culprits in chronic diseases like diabetes