If biopterin is involved for all of these, then wouldnt you think thats really important to have enough biopterin
Such is the importance of vitamin B12 in the bodys performance that a deficiency could lead to serious health problems
The studies currently available on the use of both oral and parenteral GSH are promising but represent only pilot studies for the time being
Prior studies in cancer cell lines showed that ABHD11 deficiency leads to 2-OG accumulation, which drives the formation of the l-enantiomeric ( S) form of 2-hydroxyglutarate (2-HG) and subsequent inactivation of 2-OGDDs involved in the HIF pathway (prolyl hydroxylases, PHDs), histone marks (for example, lysine demethylases, KDMs) and DNA methylation (for example, ten-eleven translocation,TET enzymes) 16,22,23
and (3) their systemic roles beyond the liver can complicate safety profiles
Annu Rev Physiol 60:121142