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This analogue also demonstrated the most pronounced detoxifying effect towards cisplatin action, resulting in a decrease in the animal death from the acute cisplatin toxicity to 17% (in comparison with 50-67% for the control animals) and restoration of a number of cisplatin-sensitive biochemical blood parameters: decrease in the activity of aspartate aminotransferase and alanine aminotransferase and downregulation of the concentration of the final products of nitrogen exchange (creatinine and urea)

J Oral Rehabil

Clearance of p16^Ink4a-Positive Senescent Cells Delays Aging-Associated Disorders

[DOI] [PubMed] [Google Scholar] Eltelib H, Fujikawa Y, Esaka M

It is produced in the liver and nerve cells in an intracellular concentration of nearly 1-10mmol/L

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