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Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: the STEP 3 randomized clinical trial

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No human timeline data exists for gut-specific applications

For metabolic studies where steady-state NAD+ elevation or weight change is the endpoint, switching routes after steady state is achieved (day 5+) has minimal impact on final outcomes, but document the change and consider it during analysis.

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