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381 In the CNS, ceruloplasmin is expressed almost exclusively in astrocytes, and its deficiency results in iron overload and formation of iron deposits

Moreover, classical methylation changes in lung cancersuch as silencing of tumor suppressors p16 and RASSF1Afurther illustrate the importance of aberrant DNA methylation in tumorigenesis [71,72,73,74,75].Together, these observations support the notion that shared methylation-regulated pathways, exemplified by KCNK3, may underlie the molecular crosstalk between hypertension and lung cancer

Moreover, -glutamyl L-DOPA has also been used as an assay substrate for clinical detection of GGT in human serum samples (Kiuchi et al., 1986)