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These structural changes greatly increase the GLP-1 like peptide's half life (t 1/2 = 1 week) compared to endogenous GLP-1 (t 1/2 = 2 minutes)

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Fras JP, Davies MJ, Rosenstock J, Prez Manghi FC, Fernndez Land L, Bergman BK, Liu B, Cui X, Brown K

Levothyroxine (or other thyroid hormone replacement) remains necessary