HC are the fractions that are digested in the small intestine and contribute to the insulin response
When stomach emptying slows significantly, the absorption curve shifts unpredictably
Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent KM, Bulchand S, Knotts TA, Shui G, Clegg DJ, Wenk MR, Pagliassotti MJ, Scherer PE, Summers SA (2011) Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
That makes it a tool clinicians may consider when aiming to work with existing physiology
Diabetes Metab 1997;23:213-8.PubMed 13
While theres no one-size-fits-all answer, research and practical experience show that timing matters for absorption and performance