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Other signs and symptoms also may develop, including irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, or increased blood pressure, respiratory rate, or heart rate

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The potential role of prostaglandins (PG), including that of PGE 1 and PGE 2 , are directly associated with inflammation and could affect the function of immune cells