and actually SARS-CoV-2 causing COVID-19, all are characterized by persistent inflammation, continuous production of reactive oxygen/nitrogen species and oxidative stress that predominate over the antioxidant defenses (GSH and free radical scavenger enzymes) resulting in cell/tissue/organ aging associated with early (premature) chronic inflammation/inflammaging. We propose that, although inflammaging was introduced for the aging process (276289), it could also apply to early (premature) tissue and organ aging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses, especially low GSH levels, in younger individuals
Like evergreen mixed with something floral maybe
Supplementary Figure 1 (download TIF Confirmed transcript variants of GSTA1-GSTA5
A cofactor is something that is required for an enzyme to catalyze a chemical reaction
For this reason, a remarkable number of inhibitors for GSTs have been synthesized as well as GSH analogues with better specificities and reduced toxicities 69,87
High levels of oxidative stress might contribute to diseases like diabetes, rheumatoid arthritis, and cancer