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Clinicians typically start patients at the middle ODT dose (5 mg) when switching from low-dose injectables (0.25 to 0.5 mg weekly) and titrate based on response

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Eur J Neurol 26(7):979985 Engel GL, Marella S, Kaun KR, Wu J, Adhikari P, Kong EC, Wolf FW (2016) Sir2/Sirt1 links acute inebriation to presynaptic changes and the development of alcohol tolerance, preference, and reward

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To date, studies have reported minimal adverse effects at typical research-level dosages

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