[11] SELECT : SELECT was a large randomized, controlled trial that enrolled over 17,000 adults with established cardiovascular disease, an elevated BMI, but no diabetes
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J., et al
While natural GLP-1 regulates blood sugar and appetite, GLP-1 agonists enhance and extend these effects, supporting better glucose control, reduced hunger, and sustainable weight management.
[8] SURPASS-2 : Tirzepatide (5, 10, 15 mg) reduced HbA1c by 2.01%2.30%, compared to 1.86% with semaglutide (1 mg)
The linkage between PEG and the drug molecule can be either stable or degradable, the latter being commonly used for prodrugs