what's the difference in tirzepatide and semaglutide vs for Weight Loss Tirzepatide vs Semaglutide: A Comprehensive

Semaglutide is not recommended in patients with heart failure New York Heart Association class IV

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This metabolic sensing function extends to regulation of key metabolic enzymes such as pyruvate dehydrogenase kinase, which is inhibited by low NAD+/NADH ratios, and lactate dehydrogenase, which is activated by high NADH levels, demonstrating the sophisticated regulatory networks that depend on NAD+ redox status

iScience (2023) 26(1):105717

This mechanism may help explain the observed weight regulation effects