tirzepatide cause fatigue Does make you feel tired? What to expect Understanding Tirzepatide Side Effects, Risks

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They're signaling molecules

There are several types of enteroendocrine cells, including I cells, which secrete cholecystokinin (CCK), K cells, which secrete gastric inhibitory peptide (GIP), L cells, which secrete glucagon-like peptide 1 and 2 (GLP-1 and GLP-2) and peptide YY (PYY), and enterochromaffin cells that secrete serotonin

The two are meant to be complementary

Seek immediate medical evaluation for severe persistent abdominal pain radiating to the back (possible pancreatitis), right upper quadrant pain after fatty meals (gallbladder disease), neck mass or difficulty swallowing (thyroid concerns), prolonged vomiting or diarrhea (dehydration risk), or allergic reactions

Another possible mechanism is accumulation of ROS at the place affected by the contrast agent