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The presence of the IgG targeting auto-antibody, rheumatoid factor (RF), is also frequently reported in RA patient sera

Glycogenesis creation of storage carbohydrate polymer from glucose and controlled by the action of the enzyme complex, glycogen synthase , and regulated by c-AMP-dependent protein kinase , promoted by the action of insulin

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Microdosing or slow dose escalation can help minimize these effects

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Notably, low-dose colchicine has demonstrated significant clinical benefits in reducing cardiovascular events in patients with chronic coronary disease and after acute MI in trials like LoDoCo2 and COLCOT, respectively (Tardif et al., 2019