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Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang Y-P

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As dopamine levels decrease, the compensatory increase in glutamatergic activity exacerbates excitotoxic damage, further promoting the loss of dopaminergic neurons

The authors concluded plainly that MK-0677 has an unfavorable safety profile in this patient population. [11] Two caveats keep this in proportion, in both directions