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Although PM shows high cure rates (94.6% in a Phase III study in India), its prolonged treatment duration poses a challenge in endemic areas

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Single-dose oral administration of EXEL-2880 resulted in prolonged inhibition of phosphorylation of constitutively phosphorylated Met in B16F10 solid tumors as well as ligand HGF-stimulated phosphorylation of Met in whole liver [78]

Resistance when drawing or injecting If the solution seems thicker than usual, requires more pressure to draw into the syringe, or feels different during injection, aggregation may have increased the viscosity