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47 A randomized placebo-controlled trial with 101 menopausal participants found a combination of 520 mg black cohosh, 400 mg chaste tree, 100 mg soy isoflavones, and 500 mg evening primrose oil, taken once daily for 12 weeks, improved hot flashes and sweating, sleep problems, mood, and irritability, as well as levels of C-reactive protein (CRP) (a marker of inflammation), LDL-cholesterol, and triglycerides

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2022;8(3): e09094

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In a recent phase 3 trial with patients with T2D and inadequate glycaemic control, the mean percentage change from baseline body weight with the 12-mg dose of retatrutide at 40 weeks was -15.3% [19]