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This not only destroys the available nitric oxideleading to severe vasoconstriction, poor tissue perfusion, and the symptoms of dysautonomiabut it also damages the eNOS enzyme itself

Trials of interventions like statins (pleiotropic metabolic modulators) and remote ischemic preconditioning (RIPC) have yielded mixed results on AKI, but notably RIPC which triggers brief limb ischemia to induce systemic protective signals has been shown in some studies to reduce plasma mtDNA and IL-1 after CPB (173)

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doi: 10.1073/pnas.93.1.269 87 MendesREZafraRPerez-EcijaRABuffoniLMartinez-MorenoATendlerMet al

[DOI] [PubMed] [Google Scholar] 15.Kuo L.E., Kitlinska J.B., Tilan J.U., Li L., Baker S.B., Johnson M.D., Lee E.W., Burnett M.S., Fricke S.T., Kvetnansky R., et al

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