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There is one differential equation for each substrate that says that the rate of change of the concentration of the substrate is the sum of the reaction velocities (M/hr) that produce it minus the sum of the reaction velocities that use it

Devader C, Khayachi A, Veyssire J, Moha Ou Maati H, Roulot M, Moreno S, Borsotto M, Martin S, Heurteaux C, Mazella J

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The historical tendency to equate pleiotropy with risk rather than opportunity appears increasingly outdated in light of contemporary successes with multi-agonist and network-based therapies