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Applying the GPX4 inhibitor RSL3 or knocking down GPX4 can enhance cell lipid peroxidation, while FSP1 overexpression attenuates RSL3-induced lipid peroxidation

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Increased activity of PRPP synthetase, in this circumstance, has the same consequences as defects in the PRPS gene that lead to superactivity of PRPP synthetase described above

doi:10.3390/biom10081181 Schwahn BC, Chen Z, Laryea MD, et al