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Effects observed were very similar to those induced during a local graft-versus-host reaction in the popliteal lymph node assay (de Bakker et al., 1990)

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Following injection, AdV particles target innate immune cells like DCs and macrophages and stimulate innate immune responses by engaging multiple pattern-recognition receptors including those that bind dsDNA in particular TLR9 to induce type I interferon secretion 8