However, it must be stressed that, despite the lack of reproductive improvement, even low doses of GLP1/E were sufficient to markedly improve the metabolic perturbations in PWA mice, thus defining an optimal scenario for occasions in which the main therapeutic objective would be metabolic normalization rather than reproductive rescue, as is actually the case for most women with PCOS, without pregnancy desire, which are submitted to continued hormonal contraception plus metformin treatment
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Individuals with greater body shape concerns and dissatisfaction with their body image, higher levels of anxiety and depression, and poorer organizational skills are more likely to discontinue treatment
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This means that the existence of widely available versions of GLP-1 drugs compounded under Section 503 A of the Food Drug & Cosmetic Act present an alternative product source for patients but do not render the innovator manufacturer exempt from MFP negotiation for those drugs
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