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Impairments in the ability to generate ATP from canonical mitochondrial pathways, such as the TCA or electron transport chain, drive additional neurophysiological impairments even after primary injury and initial ischemia resolve
It was previously reported that TSA could restore the deacetylation of H4 histone and increase the transcriptional level of glutamate receptor 2 (GluR2) in the hippocampal CA3 subregion in a rat model of pilocarpine-induced SE, thus attenuating seizure-induced neuronal injury [143]
Common side effects for both agents include nausea, vomiting, and diarrhoea, with serious risks including pancreatitis and gallbladder disease requiring urgent medical attention
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Its ability to promote deeper, more restorative sleep further underscores its significance in optimizing health and well-being
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