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These are generally mild and tend to lessen over time, especially when the dose is adjusted gradually

Efficacy and safety of novel twincretin tirzepatide, a dual GIP/GLP-1 receptor agonist, as an anti-obesity medicine in individuals without diabetes: a systematic review and meta-analysis

Patients on GLP-1 drugs tend to have EWDR for one to two years after rapid A1c improvement

A new synthetic dual agonist of GPR120/GPR40 induces GLP-1 secretion and improves glucose homeostasis in mice

However, given the novelty of this therapeutic approach, the available evidence may be influenced by publication bias and early optimism, and long-term mechanistic and clinical outcome data remain limited

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