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Statistical significance thresholds were maintained as previously described, where p-value below 0.05 was considered significant enrichment

For the global metabolite profiling in serum, the metabolites in 10 L of serum were extracted by the 390 L of pre-chilled 82% MeOH (80 C) followed by 15 min incubation at 80 C

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Phytochemical Data Collection Dr Dukes Phytochemical and Ethnobotanical Database (Duke 2016) was used to find the phytochemicals of Houttuynia cordata that display the antioxidant properties

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10.1111/ajd.12290 200 RojiM.SebastianM.LuccaJ