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T-tubule remodeling in cardiomyocytes TMAO disturbed myocardial excitation-contraction coupling by inducing Ca 2+ dysfunction (103)

190 Benzbromarone is suitable for alleviating GA and hyperuricemia combined with acute GA, however, its unsatisfactory clinical efficacy limits its application

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Aside from cytosolic amino acid sensors, intra-lysosomal amino acid sensing coincided with the identification of SLC38A9, a lysosomal transmembrane protein likely belonging to arginine transporters and an integral part of mTORC1 activation via Ragulator-RAG GTPases (Jung et al., 2015