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Thirdly, GI symptoms are common in healthy adults, with a greater frequency in individuals with diabetes even if they are not using a GLP-1RA, and these symptoms characteristically fluctuate (27)

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Once released, GLP-1 performs several important metabolic functions

At the same time, how the active protein, or peptide, in GLP-1 drugs such as oral semaglutide are absorbed through the gut can vary among peoplecausing differences in effectiveness and tolerability, McCoy says

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The Most Important Support Needs While On GLP-1 Therapy Smaller portions and early fullness are common effects of GLP-1 therapy and can make it more difficult to meet foundational nutrition targets consistently