Temporary S-glutathionylation of enzymes in the TCA cycle, ETC, or -oxidation pathway protects them from irreversible oxidation when ROS is high but may also hypothetically serve as a mechanism to diminish mitochondrial ROS production by reducing their activity [51]
However, it is typically administered to patients with a Body Mass Index (BMI) of 30 or higher, or a BMI of 27 or higher who have at least one weight-related health condition, such as hypertension or high cholesterol
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