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In patients with stage IV M1a disease, the DRR was 16% in the T-VEC group and 2% in the GM-CSF group
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it is mainly due to malabsorptive syndromes (i.e., previous GI surgery, cholestatic liver disease with low bile concentration in the intestine) and clinically presents with altered immune function, retinopathy, peripheral neuropathy, ataxia, and hemolysis (78)
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The incidence of severe hypoglycemia in pediatric patients with type 1 diabetes receiving TOUJEO as part of a multiple daily injection regimen was 6% at 26 weeks and the incidence of hypoglycemia accompanied by a self-monitored or plasma glucose value less than 54 mg/dL regardless of symptoms was 80.3%
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