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Evolution of GLP-1-based therapeutics First-generation GLP-1RAs The development of GLP-1 receptor agonists stemmed from the significant finding that natural GLP-1 had an exceptionally short half-life of about 1.5 to 5 min, due to its rapid degradation by the enzyme DPP-4 (Campbell and Drucker 2013) (Fig

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Four months later, I've dropped over 30 lbs and feel like I'm genuinely on the right trajectory

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Additional animal data show improvements in insulin sensitivity, reduction of hepatic fat (NASH models), and cardioprotective effects through improved lipid profiles

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