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This releases the Notch intracellular domain (NICD), allowing its translocation to the nucleus where it promotes expression of the lst-1 and sygl-1 stemness genes, and acts as the niche signal allowing GSCs to proliferate 15,16,17,18

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performed a meta-analysis focusing on patients with T2DM who required rescue medication for hyperglycemia and had a follow-up period of at least 24 weeks