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Furthermore, vitamin C is an antioxidant that can neutralize free radicals, which are increasingly found in the organism during oxidative stress

When glutathione levels are high, it can shift the production pathway toward pheomelanin or simply reduce the overall speed of pigment production

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In contrast, O2- is needed for melanin production, so that the enzyme tyrosinase can convert L-tyrosine into dopaquinone (Fig

Endogenous creatine synthesis also consumes methyl groups, so high creatine demand may place additional pressure on SAM-dependent methylation

When compared with the control (which exhibited about 14% spontaneous apoptosis), low dose (5 mol/ml) of ASA showed a 49% increase in apoptosis in GSH-depleted cells while 10 mol/ml ASA caused 68% increase in apoptosis after 48 h