That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route
Moreover, vitamin D deficiency has been identified as a potential risk factor for the development of hypothyroidism and thyroid autoimmunity (Tang et al., 2023
Many experience visible improvements within weeks after the first treatment
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Vitamin C A potent antioxidant that is only found externally