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In muscle tissue, transamination of BCAAs yields glutamic acid, which in turn contributes anaplerotic substrates (such -ketoglutaric acid) to the Krebs cycle, while simultaneously generating NADH to fuel mitochondrial respiration 16

Another essential component for executing ferroptosis is acyl-CoA synthetase long-chain family member 4 (ACSL4), as it influences the necessary lipid composition in ferroptosis [46]

(2021, March 17)

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