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The proposed method underwent validation according to ICH guidelines, assessing system suitability, linearity, precision, and accuracy

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As a result, transplantation of MSCs treated with Prostaglandin E1 alleviates PAH progression by lowering pulmonary artery systolic pressure and the right ventricular hypertrophy index, and by reducing right ventricular failure in the MCT-induced PAH model (Jiang et al., 2022)