For rheumatoid arthritis, they are not replacements for your DMARD or biologic but the 2025 research from centers like UCLA suggests they can be a powerful complement: less disease activity, fewer flares, lower inflammation markers, better cholesterol and blood sugar, and reduced cardiovascular risk sometimes even at low doses
You want to support your body
When to talk to your provider Contact your provider if you experience no appetite suppression after 4 weeks of consistent use, if side effects worsen rather than improve over time, if you develop mouth sores or persistent oral irritation, or if your results plateau significantly after previously good progress
You shouldnt take a GLP-1 if you have a personal or family history of certain thyroid cancers or conditions like multiple endocrine neoplasia type 2
However, the specific pathways or pathways involved are not clear enough and need further research and exploration
285, no