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These intermediate compounds can be reactive and potentially unstable

1.1 Brief history of GLP-1 discovery and development GLP-1 was discovered during research into the incretin effect, which occurs when oral glucose consumption leads to increased insulin production compared to intravenous glucose administration (Kreymann et al

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GLP-1 and similar compounds can come with side effects, especially in the beginning, such as: Nausea Digestive discomfort Reduced appetite (sometimes too much) Fatigue Peptides and other treatments may have their own side effects depending on the specific compound

Oxidative stress-induced formation of methionine sulfoxide can spontaneously react with hydroxyl radical and generates methyl radical that non-specifically and non-enzymatically methylate DNA cytosine and may affect the epigenome 38

Del Olmo-Garcia, M