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This discrepancy may stem from malabsorptive procedures altering digestive pathways and causing nutrient malabsorption, whereas restrictive surgeries primarily limit food intake through gastric volume reduction with minimal impact on digestion and absorption
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Two 10-year case-control studies over very large samples of people with diabetes ( N = 360,205 and N = 73,869, respectively) equally observed no association between GLP-1RA use and incident depression 202,203
Side effects Because semaglutide and tirzepatide both act on the gut, they tend to bring on similar side effects
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