How dysbiosis impairs GLP-1 signaling Gut dysbiosis, characterized by low bacterial diversity, overgrowth of inflammatory species, and reduced populations of beneficial bacteria, creates a cascade of metabolic problems
Shen Y, Zhang Y, Li W, Chen K, Xiang M, Ma H
In a 72-week study enrolling 3,172 overweight adults, the highest dose of orforglipron (36 mg) caused 12.4% weight loss
A proper diet and adequate sunlight may help maintain vitamin levels in the long term, but supplementation is often necessary
Can you eat normally
GrimAge V1 and V2 were computed using the Biolearn Python library ( OMICmAge was calculated using code available at CausAge, DamAge, and AdaptAge were calculated using algorithms available in the Supplementary Information of the original publication and via the ClockBase platform (www.clockbase.org) and the Biolearn Python package ( RetroAge was calculated using retroelement-based clock coefficients and scripts deposited on Zenodo (DOI: 10.5281/zenodo.11099870), which support DNA methylation EPIC v1.0 and v2.0 datasets
