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Cancer Res 2005
Many people may notice improvements in overall skin radiance within 48 weeks, while more visible changes in skin brightness and even-looking skin tone may take 812 weeks or longer of regular use
Users have reported gradual improvements in their skin tone, reduced pigmentation, and a renewed sense of confidence
Malate generated in the TCA cycle can be converted to nicotinamide adenine dinucleotide phosphate (NADPH) under the catalysis of the malic enzyme (Son et al., 2013
However, as with almost everything, this benefit may come with a cost
Long-term human studies (beyond standard clinical trial durations of several weeks to months) haven't been published
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