The research appears to be at a standstill following the cancelled 2015 Phase I study
Noticeable results often happen within 8 to 12 weeks when combined with changes in diet and being more active
Although extremely rare, hydroxocobalamin injections can also cause serious side effects such as a major allergic reaction or irregular heartbeats (palpitations)
It's a surprisingly passive process
Extending recommendations to all ages increased the impact to 104,000 hospitalizations (95% CI, 55,000-153,000) and 9,000 deaths (95% CI, 4,000-14,000) averted
Vitamins A and D also improve gut barrier integrity through modulating TJ protein expression, with reduced vitamin A consumption in rats resulting in impaired TJ barriers most likely a consequence of the decreased expression of ZO-1 and occludin also reported