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Nrf2 genes encode enzymes like heme oxygenase-1 (HO-1), NAD(P), H quinone dehydrogenase 1 (NQO1), and glutathione S-transferases (GSTs) (91)

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Gluconolactone has some interesting properties: In a 2004 study, Gluconolactone was found to prevent UV damage in mouse skin cells and has not been found to increase sun sensitivity

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Adverse effects observed in clinical trials include: Gastrointestinal effects: nausea, vomiting, diarrhoea, and constipation particularly during dose escalation