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The drug mimics the GLP-1 hormone, signalling fullness to the brain, slowing digestion, and reducing cravings

The GLP-1R and GIPR components reduce ectopic hepatic fat delivery (by reducing adipose lipolysis and improving insulin signaling), while the GCGR component simultaneously increases the livers capacity to clear the fat that does arrive

If response is suboptimal, dose may increase further

1.4 Current treatments and emerging therapeutic strategies Currently, the main treatment procedure is based on dietary restriction of TMA precursors ( Sikand and Severson, 2020 ) and frequent washing using acidic soaps

Your PlexusDx clinician can coordinate constipation management with your tirzepatide dose adjustments to find the right balance

While fibrotic lesions in GAN DIO-NASH-HCC mice did not progress to manifest cirrhosis, a pre-cirrhortic stage was suggested by spontaneous regression of steatosis which became evident at 72 weeks