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Preclinical data in glioblastomas showed that a single implant markedly reduced local recurrence and produced a median survival benefit, while pharmacokinetic studies showed therapeutic intraparenchymal temozolomide levels for over four weeks with minimal systemic exposure

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Side Effects & Safety Limited human data available

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S2CID 29708762

Therefore, GSH depletion-induced oxidative stress and cell death depend on the combination of inducer and cell-specific molecular characteristics, i.e